Waldenstrom Macroglobulinemia: Understanding The ICD-10 Code

What is Waldenstrom Macroglobulinemia ICD-10?

Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is a rare type of non-Hodgkin lymphoma characterized by the overproduction of a specific type of protein called immunoglobulin M (IgM). This condition is classified under ICD-10 code C88.0.

Code Information

Incidence, prevalence, mortality, and causes of death in
Incidence, prevalence, mortality, and causes of death in

The ICD-10 code for Waldenstrom Macroglobulinemia is C88.0. This code is used by healthcare providers to accurately diagnose and document this specific type of lymphoma in medical records and billing.

Diagnostic Related Groups (MS-DRG)

Incidence, prevalence, mortality, and causes of death in
Incidence, prevalence, mortality, and causes of death in

Waldenstrom Macroglobulinemia falls under MS-DRG 410, which is the grouping for lymphoma and leukemia with major complications or comorbidities. This DRG is used for inpatient hospital stays and helps determine the appropriate reimbursement for the treatment of this condition.

Convert to ICD-9 Code

Monoklonale Gammopathie – Wikipedia
Monoklonale Gammopathie – Wikipedia

In the previous ICD-9 coding system, Waldenstrom Macroglobulinemia was classified under code 273.3. Healthcare providers may need to convert this code to ICD-10 (C88.0) for accurate and up-to-date coding and billing purposes.

Code History

ICD--CM Diagnosis Code C
ICD–CM Diagnosis Code C

The ICD-10 code for Waldenstrom Macroglobulinemia, C88.0, was introduced in October 2015 as part of the transition from ICD-9 to ICD-10 coding systems. This update aimed to improve the accuracy and specificity of coding for various medical conditions, including lymphomas like Waldenstrom Macroglobulinemia.

Approximate Synonyms

Some approximate synonyms for Waldenstrom Macroglobulinemia include lymphoplasmacytic lymphoma, IgM monoclonal gammopathy, and lymphoplasmacytic lymphoma with IgM paraprotein.

Clinical Information

Waldenstrom Macroglobulinemia is a slow-growing type of lymphoma that primarily affects older adults. It is characterized by the abnormal proliferation of lymphocytes in the bone marrow, leading to the overproduction of IgM antibodies. This excess protein can cause symptoms such as fatigue, weakness, and enlarged lymph nodes.


The exact cause of Waldenstrom Macroglobulinemia is unknown. However, it is believed to be related to genetic mutations in the lymphocytes that lead to uncontrolled growth and proliferation. Risk factors for developing this condition include older age, male gender, and a family history of lymphomas.


Common symptoms of Waldenstrom Macroglobulinemia include fatigue, weakness, weight loss, night sweats, enlarged lymph nodes, and bleeding or bruising easily. Some patients may also experience neurological symptoms due to the effects of the abnormal protein on nerve function.


Diagnosing Waldenstrom Macroglobulinemia usually involves a combination of physical exams, blood tests, bone marrow biopsy, and imaging studies. The presence of IgM monoclonal protein in the blood or urine, along with abnormal lymphocyte counts in the bone marrow, is indicative of this condition.


Treatment for Waldenstrom Macroglobulinemia depends on the individual’s age, overall health, and the extent of the disease. Options may include watchful waiting, chemotherapy, immunotherapy, targeted therapy, and stem cell transplant. Some patients may also benefit from supportive care to manage symptoms and improve quality of life.


Waldenstrom Macroglobulinemia is a rare type of lymphoma characterized by the overproduction of IgM antibodies. Proper diagnosis and accurate coding using ICD-10 (C88.0) are essential for effective management and treatment of this condition. Healthcare providers should stay informed about new developments in research and treatment options to provide the best care for patients with Waldenstrom Macroglobulinemia.


1. Is Waldenstrom Macroglobulinemia a curable condition?

While there is no cure for Waldenstrom Macroglobulinemia, treatment can help control the disease and manage symptoms effectively.

2. Can Waldenstrom Macroglobulinemia be inherited?

There is no clear evidence

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