Wading Through ICD-10: Understanding Waldenstrom Macroglobulinemia

What is ICD 10 Waldenstrom Macroglobulinemia?

ICD 10 Waldenstrom Macroglobulinemia, also known as lymphoplasmacytic lymphoma, is a rare type of cancer that affects the lymphatic system. It is characterized by the overproduction of abnormal white blood cells, called lymphocytes, which produce large amounts of a protein called immunoglobulin M (IgM). This excessive production of IgM can lead to a variety of symptoms and complications.

Code Information

Monoklonale Gammopathie – Wikipedia
Monoklonale Gammopathie – Wikipedia

The ICD 10 code for Waldenstrom Macroglobulinemia is C88.0. This code is used to classify and code diagnoses and procedures for billing and statistical purposes. It helps healthcare providers and insurance companies track and analyze data related to this specific type of cancer.

Diagnostic Related Groups (MS-DRG)

ICD--CM Diagnosis Code C
ICD–CM Diagnosis Code C

Waldenstrom Macroglobulinemia is classified under MS-DRG 842 – Chemotherapy without Acute Leukemia as Secondary Diagnosis with MCC. This means that patients with this condition may require chemotherapy as part of their treatment plan, and may have other significant medical conditions that impact their care.

Convert to ICD-9 Code

In the ICD-9 coding system, Waldenstrom Macroglobulinemia is classified under code 273.3. This code is used to identify and document the specific diagnosis for this type of cancer in medical records and billing documentation.

Code History

The ICD 10 code for Waldenstrom Macroglobulinemia was introduced in October 2015 as part of the updated ICD-10-CM code set. This new code provides a more specific and detailed classification for this rare cancer, allowing for better tracking and analysis of cases.

Approximate Synonyms

Lymphoplasmacytic Lymphoma
Waldenstrom’s Macroglobulinemia

Clinical Information

Waldenstrom Macroglobulinemia is a slow-growing cancer that primarily affects older adults, with an average age of diagnosis in the 60s or 70s. It is more common in men than women. The exact cause of this condition is unknown, but it is thought to be related to genetic mutations that result in the uncontrolled growth of abnormal lymphocytes in the bone marrow and blood.


The exact causes of Waldenstrom Macroglobulinemia are not fully understood, but genetic factors are believed to play a role in the development of this condition. Some studies have suggested a link between certain genetic mutations and an increased risk of developing this type of cancer.


Patients with Waldenstrom Macroglobulinemia may experience a variety of symptoms, including fatigue, weakness, weight loss, numbness or tingling in the hands or feet, and frequent infections. Some individuals may also develop enlarged lymph nodes, spleen, or liver, as well as bleeding or clotting problems due to the thickening of the blood caused by the excessive production of IgM.


Diagnosing Waldenstrom Macroglobulinemia typically involves a combination of physical examination, blood tests, imaging studies, and bone marrow biopsy. Specialized tests, such as serum protein electrophoresis and immunofixation, are often used to confirm the presence of abnormal levels of IgM in the blood and diagnose this condition.


Treatment for Waldenstrom Macroglobulinemia depends on the individual patient’s symptoms, overall health, and extent of the disease. Options may include watchful waiting, chemotherapy, immunotherapy, targeted therapy, stem cell transplantation, or participation in clinical trials. Supportive care, such as blood transfusions and medications to manage symptoms, may also be recommended.


Waldenstrom Macroglobulinemia is a rare and complex type of cancer that requires specialized treatment and management. Early diagnosis and appropriate medical care are essential to improve outcomes and quality of life for patients with this condition.


Is Waldenstrom Macroglobulinemia curable?
While there is no cure for Waldenstrom Macroglobulinemia, treatment options can help manage symptoms and slow the progression of the disease.

What are the risk factors

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