Cracking The Code: Understanding The ICD-10 Code For Prolia Treatment

What is Prolia ICD-10 Code?

Prolia ICD-10 code is a specific diagnostic code used to classify and identify cases of patients who are prescribed Prolia medication. Prolia is a brand name of the drug denosumab, which is used to treat osteoporosis in postmenopausal women and men at high risk of fractures.

Code Information

ICD--CM Diagnosis Code Z
ICD–CM Diagnosis Code Z

The ICD-10 code for Prolia is M81.0. This code falls under the category of osteoporosis with pathological fracture.

Diagnostic Related Groups (MS-DRG)

Diagnostik und Therapieoptionen bei Osteoporose – BVOU Netzwerk
Diagnostik und Therapieoptionen bei Osteoporose – BVOU Netzwerk

The MS-DRG for Prolia is MS-DRG 470 – Major Joint Replacement or Reattachment of Lower Extremity with MCC or Total Ankle Replacement.

Convert to ICD-9 Code

ICD- Coding for Osteoporosis and Post Fracture Care
ICD- Coding for Osteoporosis and Post Fracture Care

The equivalent ICD-9 code for Prolia is 733.0 – Osteoporosis.

Code History

The ICD-10 code M81.0 for Prolia was implemented on October 1, 2015, as part of the transition from ICD-9 to ICD-10 coding system.

Approximate Synonyms

Denosumab therapy for osteoporosis
Denosumab treatment for osteoporosis
Osteoporosis treatment with Prolia

Clinical Information

Prolia is a monoclonal antibody that works by blocking a protein called RANKL, which plays a key role in bone breakdown. By inhibiting RANKL, Prolia helps increase bone density and reduce the risk of fractures in patients with osteoporosis.


Osteoporosis is a condition characterized by weak and brittle bones, which are more prone to fractures. The main causes of osteoporosis include hormonal changes, aging, certain medications, and lifestyle factors such as lack of exercise and poor nutrition.


Common symptoms of osteoporosis include back pain, loss of height over time, stooped posture, and fractures that occur easily, often from minor falls or even normal activities like bending over or coughing.


Diagnosis of osteoporosis is typically done through a bone mineral density (BMD) test, such as a dual-energy X-ray absorptiometry (DEXA) scan. This test measures the density of minerals in the bones and helps determine the risk of fractures.


Treatment for osteoporosis often includes a combination of medications, such as Prolia, along with lifestyle changes like regular exercise, a balanced diet high in calcium and vitamin D, and fall prevention strategies to reduce the risk of fractures.


In conclusion, Prolia ICD-10 code M81.0 is used to classify cases of osteoporosis with pathological fractures in patients prescribed Prolia medication. This drug works by inhibiting bone breakdown and increasing bone density to reduce the risk of fractures in individuals with osteoporosis.


What are the side effects of Prolia?
How often do I need to receive Prolia injections?
Can Prolia be used in men with osteoporosis?
Is Prolia covered by insurance?
Are there any contraindications for using Prolia?

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